Journal of Pathology and Translational Medicine

Young A Kim

4 Articles

Clinicopathological implications of immunohistochemical expression of TBX21, CXCR3, GATA3, CCR4, and TCF1 in nodal follicular helper T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified: Bogyeong Han, Sojung Lim, Jeemin Yim, Young Keun Song, Jiwon Koh, Sehui Kim, Cheol Lee, Young A Kim, Yoon Kyung Jeon; J Pathol Transl Med. 2024;58(2):59-71. Published online January 22, 2024; DOI: https://doi.org/10.4132/jptm.2024.01.04

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Abstract PDF Supplementary Material: Background
The classification of nodal peripheral T-cell lymphoma (PTCL) has evolved according to histology, cell-of-origin, and genetic alterations. However, the comprehensive expression pattern of follicular helper T-cell (Tfh) markers, T-cell factor-1 (TCF1), and Th1- and Th2-like molecules in nodal PTCL is unclear.
Methods
Eighty-two cases of nodal PTCL were classified into 53 angioimmunoblastic T-cell lymphomas (AITLs)/nodal T-follicular helper cell lymphoma (nTFHL)-AI, 18 PTCLs-Tfh/nTFHL–not otherwise specified (NOS), and 11 PTCLs-NOS according to the revised 4th/5th World Health Organization classifications. Immunohistochemistry for TCF1, TBX21, CXCR3, GATA3, and CCR4 was performed.
Results
TCF1 was highly expressed in up to 68% of patients with nTFHL but also in 44% of patients with PTCL-NOS (p > .05). CXCR3 expression was higher in AITLs than in non-AITLs (p = .035), whereas GATA3 expression was higher in non-AITL than in AITL (p = .007) and in PTCL-Tfh compared to AITL (p = .010). Of the cases, 70% of AITL, 44% of PTCLTfh/ nTFHL-NOS, and 36% of PTCL-NOS were subclassified as the TBX21 subtype; and 15% of AITL, 38% of PTCL-Tfh/nTFHL-NOS, and 36% of PTCL-NOS were subclassified as the GATA3 subtype. The others were an unclassified subtype. CCR4 expression was associated with poor progression-free survival (PFS) in patients with PTCL-Tfh (p < .001) and nTFHL (p = .023). The GATA3 subtype showed poor overall survival in PTCL-NOS compared to TBX21 (p = .046) and tended to be associated with poor PFS in patients with non-AITL (p = .054).
Conclusions
The TBX21 subtype was more prevalent than the GATA3 subtype in AITL. The GATA3 subtype was associated with poor prognosis in patients with non-AITL and PTCL-NOS.

Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives: Yoon Kyung Jeon, Sun Och Yoon, Jin Ho Paik, Young A Kim, Bong Kyung Shin, Hyun-Jung Kim, Hee Jeong Cha, Ji Eun Kim, Jooryung Huh, Young-Hyeh Ko; J Pathol Transl Med. 2017;51(3):224-241. Published online May 10, 2017; DOI: https://doi.org/10.4132/jptm.2017.04.09

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Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B- and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cell-of-origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized.

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Assessment of Bone Marrow Involvement in B‐Cell non‐Hodgkin Lymphoma Using Immunoglobulin Gene Rearrangement Analysis with Next‐Generation Sequencing
Min Ji Jeon, Eun Sang Yu, Dae Sik Kim, Chul Won Choi, Ha Nui Kim, Jung Ah Kwon, Soo‐Young Yoon, Jung Yoon
Journal of Clinical Laboratory Analysis.2024;[Epub] CrossRef
Thymus and lung mucosa-associated lymphoid tissue lymphoma with adenocarcinoma of the lung: a case report and literature review
Yu Pang, Daosheng Li, Yiqian Chen, Qinqin Liu, Yuheng Wu, Qingliang Teng, Yuyu Liu
World Journal of Surgical Oncology.2023;[Epub] CrossRef
Development and implementation of an automated and highly accurate reporting process for NGS-based clonality testing
Sean T. Glenn, Phillip M. Galbo, Jesse D. Luce, Kiersten Marie Miles, Prashant K. Singh, Manuel J. Glynias, Carl Morrison
Oncotarget.2023; 14(1): 450. CrossRef
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Juan-Juan Zhang, Yu-Xin Xie, Li-Lin Luo, Xuan-Tao Yang, Yi-Xing Wang, Yue Cao, Zheng-Bo Long, Wan-Pu Wang
Bioengineered.2022; 13(3): 5868. CrossRef
Lymphoproliferative disorder involving body fluid: diagnostic approaches and roles of ancillary studies
Jiwon Koh, Sun Ah Shin, Ji Ae Lee, Yoon Kyung Jeon
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Giulia Tadiotto Cicogna, Martina Ferranti, Mauro Alaibac
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Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates
Alexandra C. Hristov, Nneka I. Comfere, Claudia I. Vidal, Uma Sundram
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Ke-Ke Yu, Lei Zhu, Ji-Kai Zhao, Rui-Ying Zhao, Yu-Chen Han
Chinese Medical Journal.2019; 132(13): 1625. CrossRef
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Woojoo Lee, Eun Shin, Bo-Hyung Kim, Hyunchul Kim, Riccardo Dolcetti
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Views of dermatopathologists about clonality assays in the diagnosis of cutaneous T‐cell and B‐cell lymphoproliferative disorders
Nneka Comfere, Uma Sundram, Maria Yadira Hurley, Brian Swick
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A Next-Generation Sequencing Primer—How Does It Work and What Can It Do?
Yuriy O. Alekseyev, Roghayeh Fazeli, Shi Yang, Raveen Basran, Thomas Maher, Nancy S. Miller, Daniel Remick
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Cancers with Higher Density of Tumor-Associated Macrophages Were Associated with Poor Survival Rates: Kyong Yeun Jung, Sun Wook Cho, Young A Kim, Daein Kim, Byung-Chul Oh, Do Joon Park, Young Joo Park; J Pathol Transl Med. 2015;49(4):318-324. Published online June 17, 2015; DOI: https://doi.org/10.4132/jptm.2015.06.01

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Abstract PDF

Background
Macrophages are a component of a tumor’s microenvironment and have various roles in tumor progression and metastasis. This study evaluated the relationships between tumor-associated macrophage (TAM) density and clinical outcomes in 14 different types of human cancers. Methods: We investigated TAM density in human tissue microarray sections from 14 different types of human cancers (n = 266) and normal thyroid, lung, and breast tissues (n = 22). The five-year survival rates of each cancer were obtained from the 2011 Korea Central Cancer Registry. Results: Among 13 human cancers, excluding thyroid cancer, pancreas, lung, and gallbladder cancers had the highest density of CD163-positive macrophages (7.0±3.5%, 6.9±7.4%, and 6.9 ± 5.5%, respectively). The five-year relative survival rates of these cancers (pancreas, 8.7%; lung, 20.7%; gallbladder, 27.5%) were lower than those of other cancers. The histological subtypes in thyroid cancer exhibited significantly different CD163-positive macrophages densities (papillary, 1.8 ± 1.6% vs anaplastic, 22.9 ± 17.1%; p < .001), but no significant difference between histological subtypes was detected in lung and breast cancers. Moreover, there was no significant difference in CD163-positive macrophages densities among the TNM stages in lung, breast, and thyroid cancers. Conclusions: Cancers with higher TAM densities (pancreas, lung, anaplastic thyroid, and gallbladder) were associated with poor survival rate.

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Anupam Kotwal, Michael P. Gustafson, Svetlana Bornschlegl, Allan B. Dietz, Danae Delivanis, Mabel Ryder
Frontiers in Immunology.2024;[Epub] CrossRef
Nano-enhanced immunotherapy: Targeting the immunosuppressive tumor microenvironment
Yuzhi Jin, Yangyue Huang, Hui Ren, Huanhuan Huang, Chunyu Lai, Wenjun Wang, Zhou Tong, Hangyu Zhang, Wei Wu, Chuan Liu, Xuanwen Bao, Weijia Fang, Hongjun Li, Peng Zhao, Xiaomeng Dai
Biomaterials.2024; 305: 122463. CrossRef
Tumor microenvironment in thyroid cancer: Immune cells, patterns, and novel treatments
Beatriz Febrero, Juan José Ruiz‐Manzanera, Inmaculada Ros‐Madrid, Antonio Miguel Hernández, Esteban Orenes‐Piñero, José Manuel Rodríguez
Head & Neck.2024;[Epub] CrossRef
Research progress of immunotherapy against anaplastic thyroid cancer
Jiaqian Chen, Zuixuan Xiao, Hongyan Wu
Frontiers in Oncology.2024;[Epub] CrossRef
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Sol Yanel Núñez, Aldana Trotta, María Victoria Regge, María Sofía Amarilla, Florencia Secchiari, Jessica Mariel Sierra, María Cecilia Santilli, Mariana Gantov, Agustín Rovegno, Nicolás Richards, Carlos Ameri, Hernando Ríos Pita, Luis Rico, Mauro Mieggi, G
European Journal of Immunology.2024;[Epub] CrossRef
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Cristiana Carniti, Nicole M. Caldarelli, Luca Agnelli, Tommaso Torelli, Silva Ljevar, Sadhana Jonnalagadda, Giada Zanirato, Eugenio Fardella, Federico Stella, Daniele Lorenzini, Silvia Brich, Flavio Arienti, Anna Dodero, Annalisa Chiappella, Martina Magni
Blood Advances.2024; 8(8): 1968. CrossRef
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Jinsun Lim, Han Sai Lee, Jin-Hyung Heo, Young Shin Song
Endocrinology and Metabolism.2024; 39(2): 324. CrossRef
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Johanne Ahrenfeldt, Ditte S. Christensen, Andreas B. Østergaard, Judit Kisistók, Mateo Sokač, Nicolai J. Birkbak, Albert Rübben
PLOS ONE.2023; 18(2): e0281375. CrossRef
Current Landscape of Immunotherapy for Advanced Sarcoma
Víctor Albarrán, María Luisa Villamayor, Javier Pozas, Jesús Chamorro, Diana Isabel Rosero, María San Román, Patricia Guerrero, Patricia Pérez de Aguado, Juan Carlos Calvo, Coral García de Quevedo, Carlos González, María Ángeles Vaz
Cancers.2023; 15(8): 2287. CrossRef
Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma
Anna Martina Battaglia, Alessandro Sacco, Ilenia Aversa, Gianluca Santamaria, Camillo Palmieri, Cirino Botta, Roberto De Stefano, Maurizio Bitetto, Lavinia Petriaggi, Emanuele Giorgio, Concetta Maria Faniello, Francesco Costanzo, Flavia Biamonte
Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef
Molecular mechanisms of immunotherapy resistance in triple-negative breast cancer
Yiwen Zheng, Shujin Li, Hongchao Tang, Xuli Meng, Qinghui Zheng
Frontiers in Immunology.2023;[Epub] CrossRef
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Zhen Xu, Hyo Shik Shin, Yoo Hyung Kim, Seong Yun Ha, Jae-Kyung Won, Su-jin Kim, Young Joo Park, Sareh Parangi, Sun Wook Cho, Kyu Eun Lee
Frontiers in Immunology.2023;[Epub] CrossRef
A new approach to overcoming resistance to immunotherapy: nanotechnology
Jiangbo Shao, Ying Jin, Chunxiang Jin
Frontiers in Oncology.2023;[Epub] CrossRef
Integrative single-cell transcriptome analysis reveals immune suppressive landscape in the anaplastic thyroid cancer
Chao Feng, Yujia Tao, Chao Yu, Lirui Wang, Xiao Liu, Yuan Cao
Cancer Gene Therapy.2023; 30(12): 1598. CrossRef
Tumor-associated macrophages as a potential therapeutic target in thyroid cancers
Liya Zhu, Xiu Juan Li, Prakash Gangadaran, Xiuli Jing, Byeong-Cheol Ahn
Cancer Immunology, Immunotherapy.2023; 72(12): 3895. CrossRef
Influence of Macrophages on Vascular Invasion of Inflammatory Breast Cancer Emboli Measured Using an In Vitro Microfluidic Multi-Cellular Platform
Manasa Gadde, Melika Mehrabi-Dehdezi, Bisrat G. Debeb, Wendy A. Woodward, Marissa Nichole Rylander
Cancers.2023; 15(19): 4883. CrossRef
The Prognosis of Cancer Depends on the Interplay of Autophagy, Apoptosis, and Anoikis within the Tumor Microenvironment
Shweta Gulia, Prakash Chandra, Asmita Das
Cell Biochemistry and Biophysics.2023; 81(4): 621. CrossRef
Comprehensive analysis of BTNL9 as a prognostic biomarker correlated with immune infiltrations in thyroid cancer
Luyao Zhang, Shuang Yu, Shubin Hong, Xi Xiao, Zhihong Liao, Yanbing Li, Haipeng Xiao
BMC Medical Genomics.2023;[Epub] CrossRef
FF-10850, a Novel Liposomal Topotecan Achieves Superior Antitumor Activity via Macrophage- and Ammonia-Mediated Payload Release in the Tumor Microenvironment
Susumu Shimoyama, Ken Okada, Toshifumi Kimura, Yasushi Morohashi, Shinji Nakayama, Sayaka Kemmochi, Keiko Makita-Suzuki, Ursula A. Matulonis, Mikinaga Mori
Molecular Cancer Therapeutics.2023; 22(12): 1454. CrossRef
Estrogen-related genes for thyroid cancer prognosis, immune infiltration, staging, and drug sensitivity
Leiying Zhang, Man Zhou, Xiaoni Gao, Yang Xie, Junqi Xiao, Tao Liu, Xiangtai Zeng
BMC Cancer.2023;[Epub] CrossRef
Harnessing Immunity to Treat Advanced Thyroid Cancer
Hiroki Komatsuda, Michihisa Kono, Risa Wakisaka, Ryosuke Sato, Takahiro Inoue, Takumi Kumai, Miki Takahara
Vaccines.2023; 12(1): 45. CrossRef
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Yanzhi Song, Zhennan She, Zhenjun Huang, Shuo Wang, Xinrong Liu, Qi Zhang, Jing Sun, Donghua Di, Yihui Deng
Drug Delivery and Translational Research.2022; 12(3): 647. CrossRef
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X. Shi, L. Shu, Y. Qiao, J. Yao, H. Xie, L. Zhou, H. Wang, S. Zheng
Materials Today Nano.2022; 17: 100155. CrossRef
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Nao Nishida-Aoki, Taranjit S. Gujral
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Hao Tan, Lidong Wang, Zhen Liu
Frontiers in Genetics.2022;[Epub] CrossRef
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Biomedicines.2022; 10(2): 219. CrossRef
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Cancers.2022; 14(4): 1061. CrossRef
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Jamie A. Moore, Jayna J. Mistry, Charlotte Hellmich, Rebecca H. Horton, Edyta E. Wojtowicz, Aisha Jibril, Matthew Jefferson, Thomas Wileman, Naiara Beraza, Kristian M. Bowles, Stuart A. Rushworth
Journal of Clinical Investigation.2022;[Epub] CrossRef
Integration of chemokine signaling with non-coding RNAs in tumor microenvironment and heterogeneity in different cancers
Shweta Arora, Salman Khan, Almaz Zaki, Gulnaz Tabassum, Mohd Mohsin, Humaira Naaz Bhutto, Tanveer Ahmad, Tasneem Fatma, Mansoor Ali Syed
Seminars in Cancer Biology.2022; 86: 720. CrossRef
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Ophélie Delcorte, Catherine Spourquet, Pascale Lemoine, Jonathan Degosserie, Patrick Van Der Smissen, Nicolas Dauguet, Axelle Loriot, Jeffrey A. Knauf, Laurent Gatto, Etienne Marbaix, James A. Fagin, Christophe E. Pierreux
Biomedicines.2022; 10(4): 755. CrossRef
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Johannes Wach, Tim Lampmann, Ági Güresir, Hartmut Vatter, Ulrich Herrlinger, Albert Becker, Marieta Toma, Michael Hölzel, Erdem Güresir
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Qi Liu, Wei Sun, Hao Zhang
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Hualin Chen, Gang Chen
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Xin Liu, Qiang Song, Daohan Wang, Yubiao Liu, Zhixiang Zhang, Weihua Fu
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International Journal of Molecular Sciences.2022; 23(14): 7902. CrossRef
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Hei Jung Kim, Young Rae Ji, You Mie Lee
Archives of Pharmacal Research.2022; 45(6): 401. CrossRef
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Son Hai Vu, Preethi Vetrivel, Jongmin Kim, Myeong-Sok Lee
International Journal of Molecular Sciences.2022; 23(18): 10906. CrossRef
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Omar Samir, Naohiro Kobayashi, Teppei Nishino, Mennatullah Siyam, Manoj Kumar Yadav, Yuri Inoue, Satoru Takahashi, Michito Hamada
International Journal of Molecular Sciences.2022; 23(17): 9945. CrossRef
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Yanqing Wang, Yi Zhao, Yong Li, Zemin Luo, Hongzhu Chen, Yuan Li
Journal of Sensors.2022; 2022: 1. CrossRef
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Jieheng Wu, Xinlei Liu, Jiangwei Wu, Chunju Lou, Qiaoling Zhang, Huiping Chen, Zeyang Yang, Shiqi Long, Yun Wang, Zhenling Shang, Zuquan Hu, Rui Zhang, Jian Zhang, Zhu Zeng
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Eunah Shin, Ja Seung Koo
International Journal of Molecular Sciences.2022; 23(20): 12578. CrossRef
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Luz Maria Palacios, Victoria Peyret, María Estefania Viano, Romina Celeste Geysels, Yair Aron Chocobar, Ximena Volpini, Claudia Gabriela Pellizas, Juan Pablo Nicola, Claudia Cristina Motran, María Cecilia Rodriguez-Galan, Laura Fozzatti
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Kun Wang, Haomin Li, Junyu Zhao, Jinming Yao, Yiran Lu, Jianjun Dong, Jie Bai, Lin Liao
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Xiaonan Xiang, Jianguo Wang, Di Lu, Xiao Xu
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International Journal of Molecular Sciences.2021; 22(14): 7666. CrossRef
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Cancers.2021; 13(16): 4127. CrossRef
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Linnéa La Fleur, Johan Botling, Fei He, Catarina Pelicano, Chikai Zhou, Chenfei He, Giorgia Palano, Artur Mezheyeuski, Patrick Micke, Jeffrey V. Ravetch, Mikael C. I. Karlsson, Dhifaf Sarhan
Cancer Research.2021; 81(4): 956. CrossRef
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Elisa Stellaria Grassi, Viola Ghiandai, Luca Persani
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R. Zou, Y. Wang, F. Ye, X. Zhang, M. Wang, S. Cui
Clinical and Translational Oncology.2021; 23(11): 2237. CrossRef
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Cancers.2021; 13(5): 1086. CrossRef
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Cinthia Carolina Stempin, Romina Celeste Geysels, Sunmi Park, Luz Maria Palacios, Ximena Volpini, Claudia Cristina Motran, Eva Virginia Acosta Rodríguez, Juan Pablo Nicola, Sheue-yann Cheng, Claudia Gabriela Pellizas, Laura Fozzatti
Cancers.2021; 13(19): 4821. CrossRef
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Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
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Farshad Moradi Kashkooli, M. Soltani
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Evan Morgan, Anupama Suresh, Akaansha Ganju, Daniel G. Stover, Robert Wesolowski, Sagar Sardesai, Anne Noonan, Raquel Reinbolt, Jeffrey VanDeusen, Nicole Williams, Mathew A. Cherian, Zaibo Li, Gregory Young, Marilly Palettas, Julie Stephens, Joseph Liu, A
World Journal of Surgical Oncology.2020;[Epub] CrossRef
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JCI Insight.2020;[Epub] CrossRef
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Alireza Labani-Motlagh, Mehrnoush Ashja-Mahdavi, Angelica Loskog
Frontiers in Immunology.2020;[Epub] CrossRef
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PLOS ONE.2020; 15(5): e0233789. CrossRef
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Marta Torres, Miguel Ángel Martinez-Garcia, Francisco Campos-Rodriguez, David Gozal, Josep M. Montserrat, Daniel Navajas, Ramon Farré, Isaac Almendros
Menopause.2020; 27(6): 706. CrossRef
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Alexandria Harris, Lingyun Lyu, Tamara Wasserman‐Winko, Susan George, Jonas T. Johnson, Marci Lee Nilsen
Otolaryngology–Head and Neck Surgery.2020; 163(4): 763. CrossRef
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Binfan Chen, Ang Gao, Bin Tu, Yonghui Wang, Xiaolu Yu, Yingshu Wang, Yanfeng Xiu, Bing Wang, Yakun Wan, Yongzhuo Huang
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The Thyroid Tumor Microenvironment: Potential Targets for Therapeutic Intervention and Prognostication
Laura MacDonald, Jonathan Jenkins, Grace Purvis, Joshua Lee, Aime T. Franco
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Prognosis of Macrophage Density in the Absence of Neutrophils in Differentiated Thyroid Cancer
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Journal of Molecular Liquids.2020; 320: 114363. CrossRef
Tumor‑associated macrophages in lung cancer: Friendly or evil? (Review)
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Molecular Medicine Reports.2020;[Epub] CrossRef
Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation
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Cellular Oncology.2020; 43(6): 1161. CrossRef
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Frontiers in Endocrinology.2020;[Epub] CrossRef
The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy
Zhe Ge, Shuzhe Ding
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Immune Cell Confrontation in the Papillary Thyroid Carcinoma Microenvironment
Zhenyu Xie, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Yu Lun, Jian Zhang
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Early macrophage infiltrates impair pancreatic cancer cell growth by TNF-α secretion
Cansu Tekin, Hella L. Aberson, Maarten F. Bijlsma, C. Arnold Spek
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Circulating CEA‐dNLR score predicts clinical outcome of metastatic gallbladder cancer patient
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Papillary thyroid carcinoma behavior: clues in the tumor microenvironment
Kensey Bergdorf, Donna C Ferguson, Mitra Mehrad, Kim Ely, Thomas Stricker, Vivian L Weiss
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Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
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Tumor-associated macrophage infiltration in meningioma
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International Journal of Molecular Sciences.2019; 20(18): 4413. CrossRef
Caveolin-2 deficiency induces a rapid anti-tumor immune response prior to regression of implanted murine lung carcinoma tumors
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Huige Peng, Binfan Chen, Wei Huang, Yubo Tang, Yifan Jiang, Wenyuan Zhang, Yongzhuo Huang
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Melissa N. Zimel, Chloe B. Horowitz, Vinagolu K. Rajasekhar, Alexander B. Christ, Xin Wei, Jianbo Wu, Paulina M. Wojnarowicz, Dong Wang, Steven R. Goldring, P. Edward Purdue, John H. Healey
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Kristian Krpina, Emina Babarović, Josip Španjol, Gordana Đorđević, Tobias Maurer, Nives Jonjić
Wiener klinische Wochenschrift.2016; 128(7-8): 248. CrossRef
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Jacalin-Activated Macrophages Exhibit an Antitumor Phenotype
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Shujun Sun, Xinliang Pan, Limin Zhao, Jianming Zhou, Hongzeng Wang, Yonghong Sun
Clinical and Experimental Otorhinolaryngology.2016; 9(3): 270. CrossRef
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Xiu Juan Li, Prakash Gangadaran, Senthilkumar Kalimuthu, Ji Min Oh, Liya Zhu, Shin Young Jeong, Sang‐Woo Lee, Jaetae Lee, Byeong‐Cheol Ahn
International Journal of Cancer.2016; 139(11): 2583. CrossRef
Perspectives for immunotherapy in endocrine cancer
S Latteyer, V Tiedje, B Schilling, D Führer
Endocrine-Related Cancer.2016; 23(10): R469. CrossRef
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Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park
Endocrinology and Metabolism.2016; 31(3): 469. CrossRef
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Oncotarget.2016; 7(17): 23909. CrossRef
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RSC Advances.2015; 5(126): 104110. CrossRef

Detection of Survivin and COX-2 in Thyroid Carcinoma: Anaplastic Carcinoma Shows Overexpression of Nuclear Survivin and Low COX-2 Expression: Young A Kim, Meesoo Chang, Young Joo Park, Ji Eun Kim; Korean J Pathol. 2012;46(1):55-60. Published online February 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.55

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Abstract PDF

Background

Overexpression of survivin, a member of the inhibitors of apoptosis protein, has been reported in various carcinomas, and its interaction with cyclooxygenase 2 (COX-2) results in accelerated tumor progression. The purpose of this study is to investigate the immunohistochemical expression of survivin and COX-2 in benign and malignant thyroid tissues and to define its association with pathologic and clinical features.

Methods

We examined expression of survivin and COX-2 by immunohistochemistry in 334 benign and malignant thyroid tissues and evaluated their clinical significance.

Results

Expression of survivin showed an increase along the spectrum of thyroid carcinoma progression; rarely positive in adenomatous goiter, moderately positive in papillary carcinoma, and strongly positive in anaplastic carcinoma (AC). Papillary microcarcinoma revealed the highest COX-2 positivity and AC demonstrated the lowest positivity among thyroid cancers. Node negative carcinomas showed higher COX-2 expression than node positive tumors. Survivin expression did not correlate with COX-2.

Conclusions

Our findings suggest that survivin overexpression may be related to the pathogenesis of AC and can be a predictor of disease progression. COX-2 may be involved in the early phase of thyroid carcinoma.

Citations

Citations to this article as recorded by

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Pathology - Research and Practice.2019; 215(4): 619. CrossRef
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Xiaoyan Fu, Huayong Zhang, Zhipeng Chen, Zhongyuan Yang, Dingbo Shi, Tianrun Liu, Weichao Chen, Fan Yao, Xuan Su, Wuguo Deng, Miao Chen, Ankui Yang
Cell Death & Disease.2019;[Epub] CrossRef
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Pathology - Research and Practice.2014; 210(1): 30. CrossRef

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